IUPAC Name	4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one	Source
Source	PubChem
URL	https://pubchem.ncbi.nlm.nih.gov
Description	Data deposited in or computed by PubChem

InChI	InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3	Source
Source	PubChem
URL	https://pubchem.ncbi.nlm.nih.gov
Description	Data deposited in or computed by PubChem

InChI Key	PJVWKTKQMONHTI-UHFFFAOYSA-N	Source
Source	PubChem
URL	https://pubchem.ncbi.nlm.nih.gov
Description	Data deposited in or computed by PubChem

Canonical SMILES	CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O	Source
Source	PubChem
URL	https://pubchem.ncbi.nlm.nih.gov
Description	Data deposited in or computed by PubChem

Molecular Formula	C19H16O4	Source
Record name	WARFARIN
Source	CAMEO Chemicals
URL	https://cameochemicals.noaa.gov/chemical/5240
Description	CAMEO Chemicals is a chemical database designed for people who are involved in hazardous material incident response and planning. CAMEO Chemicals contains a library with thousands of datasheets containing response-related information and recommendations for hazardous materials that are commonly transported, used, or stored in the United States. CAMEO Chemicals was developed by the National Oceanic and Atmospheric Administration's Office of Response and Restoration in partnership with the Environmental Protection Agency's Office of Emergency Management.
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Record name	WARFARIN
Source	ILO-WHO International Chemical Safety Cards (ICSCs)
URL	https://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0821
Description	The International Chemical Safety Cards (ICSCs) are data sheets intended to provide essential safety and health information on chemicals in a clear and concise way. The primary aim of the Cards is to promote the safe use of chemicals in the workplace.
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Source	PubChem
URL	https://pubchem.ncbi.nlm.nih.gov
Description	Data deposited in or computed by PubChem

DSSTOX Substance ID	DTXSID5023742	Source
Record name	Warfarin
Source	EPA DSSTox
URL	https://comptox.epa.gov/dashboard/DTXSID5023742
Description	DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.

Molecular Weight	308.3 g/mol	Source
Source	PubChem
URL	https://pubchem.ncbi.nlm.nih.gov
Description	Data deposited in or computed by PubChem

Physical Description	Warfarin is an odorless and colorless solid. Used as a rodenticide for Norway rats and for house mice. (EPA, 1998), Colorless, odorless, crystalline powder. [rodenticide]; [NIOSH], Solid, COLOURLESS-TO-WHITE POWDER., Colorless, odorless, crystalline powder or solid., Colorless, odorless, crystalline powder. [Note: Rodenticide.]	Source
Record name	WARFARIN
Source	CAMEO Chemicals
URL	https://cameochemicals.noaa.gov/chemical/5240
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Record name	Warfarin
Source	Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
URL	https://haz-map.com/Agents/673
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Record name	Warfarin
Source	Human Metabolome Database (HMDB)
URL	http://www.hmdb.ca/metabolites/HMDB0001935
Description	The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.
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Record name	WARFARIN
Source	ILO-WHO International Chemical Safety Cards (ICSCs)
URL	https://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0821
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Record name	WARFARIN
Source	Occupational Safety and Health Administration (OSHA)
URL	https://www.osha.gov/chemicaldata/714
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Explanation	Materials created by the federal government are generally part of the public domain and may be used, reproduced and distributed without permission. Therefore, content on this website which is in the public domain may be used without the prior permission of the U.S. Department of Labor (DOL). Warning: Some content - including both images and text - may be the copyrighted property of others and used by the DOL under a license.

Record name	Warfarin
Source	The National Institute for Occupational Safety and Health (NIOSH)
URL	https://www.cdc.gov/niosh/npg/npgd0665.html
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Boiling Point	Decomposes (NIOSH, 2023), decomposes, Decomposes	Source
Record name	WARFARIN
Source	CAMEO Chemicals
URL	https://cameochemicals.noaa.gov/chemical/5240
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Record name	WARFARIN
Source	Occupational Safety and Health Administration (OSHA)
URL	https://www.osha.gov/chemicaldata/714
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Record name	Warfarin
Source	The National Institute for Occupational Safety and Health (NIOSH)
URL	https://www.cdc.gov/niosh/npg/npgd0665.html
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Explanation	The information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.

Solubility	0.002 % (NIOSH, 2023), Solubility: 1 g in 1.5 mL water, 1.9 mL alcohol, >10,000 mL chloroform, >10,000 mL ether /Warfarin potassium/, In water, 17 mg/L at 20 °C, Soluble in acetone, dioxane; moderately soluble in methanol, ethanol, isopropanol, some oils; freely soluble in alkaline aqueous solution (forms a water-sol sodium salt); practically insoluble in benzene, cyclohexane, Skellysolves A and B., In acetone 65, chloroform 56, dioxane 100 (all in g/L, 20 °C), 0.017 mg/mL at 20 °C, Solubility in water, g/100ml at 20 °C: 0.0017 (very poor), 0.002%	Source
Record name	WARFARIN
Source	CAMEO Chemicals
URL	https://cameochemicals.noaa.gov/chemical/5240
Description	CAMEO Chemicals is a chemical database designed for people who are involved in hazardous material incident response and planning. CAMEO Chemicals contains a library with thousands of datasheets containing response-related information and recommendations for hazardous materials that are commonly transported, used, or stored in the United States. CAMEO Chemicals was developed by the National Oceanic and Atmospheric Administration's Office of Response and Restoration in partnership with the Environmental Protection Agency's Office of Emergency Management.
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Record name	Warfarin
Source	DrugBank
URL	https://www.drugbank.ca/drugs/DB00682
Description	The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.
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Record name	WARFARIN
Source	Hazardous Substances Data Bank (HSDB)
URL	https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1786
Description	The Hazardous Substances Data Bank (HSDB) is a toxicology database that focuses on the toxicology of potentially hazardous chemicals. It provides information on human exposure, industrial hygiene, emergency handling procedures, environmental fate, regulatory requirements, nanomaterials, and related areas. The information in HSDB has been assessed by a Scientific Review Panel.

Record name	Warfarin
Source	Human Metabolome Database (HMDB)
URL	http://www.hmdb.ca/metabolites/HMDB0001935
Description	The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.
Explanation	HMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.

Record name	WARFARIN
Source	ILO-WHO International Chemical Safety Cards (ICSCs)
URL	https://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0821
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Record name	Warfarin
Source	The National Institute for Occupational Safety and Health (NIOSH)
URL	https://www.cdc.gov/niosh/npg/npgd0665.html
Description	The NIOSH Pocket Guide to Chemical Hazards is intended as a source of general industrial hygiene information on several hundred chemicals/classes for workers, employers, and occupational health professionals. Read more: https://www.cdc.gov/niosh/npg/
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Density	Relative density (water = 1): 1.4	Source
Record name	WARFARIN
Source	ILO-WHO International Chemical Safety Cards (ICSCs)
URL	https://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0821
Description	The International Chemical Safety Cards (ICSCs) are data sheets intended to provide essential safety and health information on chemicals in a clear and concise way. The primary aim of the Cards is to promote the safe use of chemicals in the workplace.
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Vapor Density	Relative vapor density (air = 1): 10.6	Source
Record name	WARFARIN
Source	ILO-WHO International Chemical Safety Cards (ICSCs)
URL	https://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0821
Description	The International Chemical Safety Cards (ICSCs) are data sheets intended to provide essential safety and health information on chemicals in a clear and concise way. The primary aim of the Cards is to promote the safe use of chemicals in the workplace.
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Vapor Pressure	0.09 mmHg at 71 °F (NIOSH, 2023), 0.09 [mmHg], 1.5X10-3 mPa /1.125X10-8 mm Hg/ at 25 °C, Vapor pressure, Pa at 20 °C: (negligible), 0.09 mmHg at 71 °F, (71 °F): 0.09 mmHg	Source
Record name	WARFARIN
Source	CAMEO Chemicals
URL	https://cameochemicals.noaa.gov/chemical/5240
Description	CAMEO Chemicals is a chemical database designed for people who are involved in hazardous material incident response and planning. CAMEO Chemicals contains a library with thousands of datasheets containing response-related information and recommendations for hazardous materials that are commonly transported, used, or stored in the United States. CAMEO Chemicals was developed by the National Oceanic and Atmospheric Administration's Office of Response and Restoration in partnership with the Environmental Protection Agency's Office of Emergency Management.
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Record name	Warfarin
Source	Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
URL	https://haz-map.com/Agents/673
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Record name	WARFARIN
Source	Hazardous Substances Data Bank (HSDB)
URL	https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1786
Description	The Hazardous Substances Data Bank (HSDB) is a toxicology database that focuses on the toxicology of potentially hazardous chemicals. It provides information on human exposure, industrial hygiene, emergency handling procedures, environmental fate, regulatory requirements, nanomaterials, and related areas. The information in HSDB has been assessed by a Scientific Review Panel.

Record name	WARFARIN
Source	ILO-WHO International Chemical Safety Cards (ICSCs)
URL	https://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0821
Description	The International Chemical Safety Cards (ICSCs) are data sheets intended to provide essential safety and health information on chemicals in a clear and concise way. The primary aim of the Cards is to promote the safe use of chemicals in the workplace.
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Record name	WARFARIN
Source	Occupational Safety and Health Administration (OSHA)
URL	https://www.osha.gov/chemicaldata/714
Description	The OSHA Occupational Chemical Database contains over 800 entries with information such as physical properties, exposure guidelines, etc.
Explanation	Materials created by the federal government are generally part of the public domain and may be used, reproduced and distributed without permission. Therefore, content on this website which is in the public domain may be used without the prior permission of the U.S. Department of Labor (DOL). Warning: Some content - including both images and text - may be the copyrighted property of others and used by the DOL under a license.

Record name	Warfarin
Source	The National Institute for Occupational Safety and Health (NIOSH)
URL	https://www.cdc.gov/niosh/npg/npgd0665.html
Description	The NIOSH Pocket Guide to Chemical Hazards is intended as a source of general industrial hygiene information on several hundred chemicals/classes for workers, employers, and occupational health professionals. Read more: https://www.cdc.gov/niosh/npg/
Explanation	The information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.

Mechanism of Action	Warfarin is a [vitamin K] antagonist which acts to inhibit the production of vitamin K by vitamin K epoxide reductase. The reduced form of vitamin K, vitamin KH₂ is a cofactor used in the γ-carboxylation of coagulation factors VII, IX, X, and thrombin. Carboxylation induces a conformational change allowing the factors to bind Ca²⁺ and to phospholipid surfaces. Uncarboxylated factors VII, IX, X, and thrombin are biologically inactive and therefore serve to interrupt the coagulation cascade. The endogenous anticoagulation proteins C and S also require γ-carboxylation to function. This is particularly true in the case of thrombin which must be activated in order to form a thrombus. vitamin KH₂ is converted to vitamin K epoxide as part of the γ-carboxylation reaction catalyzed by γ-glutamyl carboxylase. Vitamin K epoxide is then converted to vitamin K₁ by vitamin K epoxide reductase then back to vitamin KH₂ by vitamin K reductase. Warfarin binds to vitamin K epoxide reductase complex subunit 1 and irreversibly inhibits the enzyme thereby stopping the recycling of vitamin K by preventing the conversion of vitamin K epoxide to vitamin K₁. This process creates a hypercoagulable state for a short time as proteins C and S degrade first with half lives of 8 and 24 hours, with the exception of factor VII which has a half life of 6 hours. Factors IX, X, and finally thrombin degrade later with half lives of 24, 36, and 50 hours resulting in a dominant anticoagulation effect. In order to reverse this anticoagulation vitamin K must be supplied, either exogenously or by removal of the vitamin K epoxide reductase inhibition, and time allowed for new coagulation factors to be synthesized. It takes approximately 2 days for new coagulation factors to be synthesized in the liver. Vitamin K₂, functionally identical to vitamin K₁, is synthesized by gut bacteria leading to interactions with antibiotics as elimination of these bacteria can reduce vitamin K₂	Source
Record name	Warfarin
Source	DrugBank
URL	https://www.drugbank.ca/drugs/DB00682
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Record name	WARFARIN
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URL	https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1786
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Color/Form	Crystals from alcohol, White powder, The racemate forms colorless crystals
CAS No.	81-81-2	Source
Record name	WARFARIN
Source	CAMEO Chemicals
URL	https://cameochemicals.noaa.gov/chemical/5240
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Record name	(±)-Warfarin
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Record name	Warfarin [INN:BAN]
Source	ChemIDplus
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Record name	Warfarin
Source	DrugBank
URL	https://www.drugbank.ca/drugs/DB00682
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Record name	warfarin
Source	DTP/NCI
URL	https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=757385
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Record name	warfarin
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Record name	2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-
Source	EPA Chemicals under the TSCA
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Record name	Warfarin
Source	EPA DSSTox
URL	https://comptox.epa.gov/dashboard/DTXSID5023742
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Record name	Warfarin
Source	European Chemicals Agency (ECHA)
URL	https://echa.europa.eu/substance-information/-/substanceinfo/100.001.253
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Record name	WARFARIN
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Record name	WARFARIN
Source	Hazardous Substances Data Bank (HSDB)
URL	https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1786
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Record name	Warfarin
Source	Human Metabolome Database (HMDB)
URL	http://www.hmdb.ca/metabolites/HMDB0001935
Description	The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.
Explanation	HMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.

Record name	WARFARIN
Source	ILO-WHO International Chemical Safety Cards (ICSCs)
URL	https://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0821
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Record name	WARFARIN
Source	Occupational Safety and Health Administration (OSHA)
URL	https://www.osha.gov/chemicaldata/714
Description	The OSHA Occupational Chemical Database contains over 800 entries with information such as physical properties, exposure guidelines, etc.
Explanation	Materials created by the federal government are generally part of the public domain and may be used, reproduced and distributed without permission. Therefore, content on this website which is in the public domain may be used without the prior permission of the U.S. Department of Labor (DOL). Warning: Some content - including both images and text - may be the copyrighted property of others and used by the DOL under a license.

Record name	Coumarin, 3-(alpha-acetonylbenzyl)-4-hydroxy-
Source	The National Institute for Occupational Safety and Health (NIOSH)
URL	https://www.cdc.gov/niosh-rtecs/GN456D70.html
Description	The NIOSH Pocket Guide to Chemical Hazards (NPG) provides general industrial hygiene information for workers, employers, and occupational health professionals. It contains safety information and hazard data related to chemical substances or mixtures.
Explanation	The information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.

Melting Point	322 °F (EPA, 1998), 161 °C, 322 °F	Source
Record name	WARFARIN
Source	CAMEO Chemicals
URL	https://cameochemicals.noaa.gov/chemical/5240
Description	CAMEO Chemicals is a chemical database designed for people who are involved in hazardous material incident response and planning. CAMEO Chemicals contains a library with thousands of datasheets containing response-related information and recommendations for hazardous materials that are commonly transported, used, or stored in the United States. CAMEO Chemicals was developed by the National Oceanic and Atmospheric Administration's Office of Response and Restoration in partnership with the Environmental Protection Agency's Office of Emergency Management.
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Record name	Warfarin
Source	DrugBank
URL	https://www.drugbank.ca/drugs/DB00682
Description	The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.
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Record name	WARFARIN
Source	Hazardous Substances Data Bank (HSDB)
URL	https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1786
Description	The Hazardous Substances Data Bank (HSDB) is a toxicology database that focuses on the toxicology of potentially hazardous chemicals. It provides information on human exposure, industrial hygiene, emergency handling procedures, environmental fate, regulatory requirements, nanomaterials, and related areas. The information in HSDB has been assessed by a Scientific Review Panel.

Record name	Warfarin
Source	Human Metabolome Database (HMDB)
URL	http://www.hmdb.ca/metabolites/HMDB0001935
Description	The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.
Explanation	HMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.

Record name	WARFARIN
Source	ILO-WHO International Chemical Safety Cards (ICSCs)
URL	https://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0821
Description	The International Chemical Safety Cards (ICSCs) are data sheets intended to provide essential safety and health information on chemicals in a clear and concise way. The primary aim of the Cards is to promote the safe use of chemicals in the workplace.
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Record name	WARFARIN
Source	Occupational Safety and Health Administration (OSHA)
URL	https://www.osha.gov/chemicaldata/714
Description	The OSHA Occupational Chemical Database contains over 800 entries with information such as physical properties, exposure guidelines, etc.
Explanation	Materials created by the federal government are generally part of the public domain and may be used, reproduced and distributed without permission. Therefore, content on this website which is in the public domain may be used without the prior permission of the U.S. Department of Labor (DOL). Warning: Some content - including both images and text - may be the copyrighted property of others and used by the DOL under a license.

Record name	Warfarin
Source	The National Institute for Occupational Safety and Health (NIOSH)
URL	https://www.cdc.gov/niosh/npg/npgd0665.html
Description	The NIOSH Pocket Guide to Chemical Hazards is intended as a source of general industrial hygiene information on several hundred chemicals/classes for workers, employers, and occupational health professionals. Read more: https://www.cdc.gov/niosh/npg/
Explanation	The information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.

Synthesis routes and methods I

Procedure details

Control, blank, and experimental reaction mixtures were made for each experiment. Control and blank reaction mixtures were made up with vitamin K and without vitamin K, respectively. Experimental reaction mixtures contained both vitamin K and a vitamin K antagonist. The control reaction mixture contained 3.00 ml of microsomal suspension, 0.81 ml of buffer II, 1.20 ml of an ATP-generating system (final concentrations: 1 mM ATP, 10 mM phosphocreatine, 2.5 mM Mg[acetate]2 ·4H2O, 20 μg/ml creatine phosphokinase [52 U/ml]), 0.60 ml of NADH (final concentration 2 mM), 0.30 ml of dithiothreitol (final concentration 7 mM) dissolved in buffer II, 0.060 ml of NaH14CO3 (1.0 μCi/μl; added 0.5 min prior to reaction initiation), and at the time of reaction initiation 0.030 ml of vitamin K1 (final concentration 20 μg/ml) diluted in 0.85% sodium chloride solution. This vitamin K concentration is associated with maximal in vitro incorporation of added H14CO3 into vitamin K-dependent substrate proteins (J. Biol. Chem. 251, 2770-2776). The blank reaction mixture consisted of the same components except that vitamin K was replaced by an equal volume of isotonic saline. The experimental reaction mixtures were made up in the same way as the control reaction mixtures with the exceptions that: (1) a volume of buffer II was replaced by a volume of buffer II containing an inhibitor of vitamin K-dependent carboxylation, and (2) all individual volumes were two-thirds of those in the control reaction mixtures. The sodium salts of TCP, phenindione, and warfarin were formed in aqueous sodium hydroxide solution (J. Am. Chem. Soc. 83, 2676-2679) and were freely soluble in buffer II at all concentrations used in these studies. Chloro-K1 was formulated as an oil-in-water emulsion with Tween 80 (5% v/v final concentration), while chloro-K3 was formulated as a suspension in Tween 80 (5% v/v final concentration) (Molecular Pharmacology 10, 373-380).

Name

sodium hydroxide

Quantity

0 (± 1) mol

Type

reactant

Reaction Step One

Name

vitamin K1

Quantity

0.03 mL

Type

reactant

Reaction Step Two

[Compound]

Name

vitamin K

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Three

[Compound]

Name

( 1 )

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Four

[Compound]

Name

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Five

[Compound]

Name

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Six

[Compound]

Name

vitamin K

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Seven

[Compound]

Name

( 2 )

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Seven

Name

sodium chloride

Quantity

0 (± 1) mol

Type

solvent

Reaction Step Eight

[Compound]

Name

vitamin K

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Nine

[Compound]

Name

vitamin K

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Ten

[Compound]

Name

vitamin K

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Eleven

[Compound]

Name

vitamin K

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Twelve

[Compound]

Name

microsomal suspension

Quantity

3 mL

Type

reactant

Reaction Step Thirteen

[Compound]

Name

Quantity

0 (± 1) mol

Type

reactant

Reaction Step Fourteen

Name

ATP

Quantity

1.2 mL

Type

reactant

Reaction Step Fifteen

[Compound]

Name

sodium salts

Name

phenindione

Name

warfarin

Details

Synthesis routes and methods II

Procedure details

To show that non-binding compounds do not significantly influence the FT-IR spectrum of a biological macromolecule when mixed with the biological macromolecule, 3 μg of NMT was mixed with 10 μg each of Bacitracin (trace 1), Erythromycin (2), Fusidic Acid (3) and a fungal extract (4) and a differential FT-IR spectrum of each sample was obtained (FIG. 3). The non-binding compounds did not alter the spectrum of NMT. However, a nonspecific binding compound, Warfarin (60 μg), did produce a detectable peak shift for NMT.

Name

Bacitracin

Quantity

10 μg

Type

reactant

Reaction Step One

Name

Erythromycin

Quantity

0 (± 1) mol

Type

reactant

Reaction Step One

Name

Fusidic Acid

Quantity

0 (± 1) mol

Type

reactant

Reaction Step One

Name

Warfarin

Details

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Synthesis routes and methods I

Procedure details

Synthesis routes and methods II

Procedure details

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