Potassium iodide
描述
碘化钾是一种无机化合物,化学式为 KI。它是一种金属卤化盐,钾阳离子 (K⁺) 和碘阴离子 (I⁻) 之间形成离子键。该化合物呈现无色至白色立方晶体、粉末或白色颗粒。 碘化钾广泛应用于医药、辐射防护以及作为膳食补充剂 .
作用机制
碘化钾主要作用于甲状腺。它抑制甲状腺激素的合成和释放,降低甲状腺血管性,并增加甲状腺滤泡中胶体的积累。这导致甲状腺变硬,细胞尺寸减小,结合碘水平升高。 此外,碘化钾阻止放射性碘被甲状腺吸收,从而降低辐射照射期间患甲状腺癌的风险 .
类似化合物:
碘酸钾 (KIO₃): 用作食盐中的碘补充剂,并在辐射事故中用于阻断甲状腺。
碘化钠 (NaI): 在与碘化钾类似的应用中使用,但溶解度和反应性不同。
碘化钙 (CaI₂): 用于动物饲料以及作为各种应用中的碘源
碘化钾的独特性: 碘化钾的独特之处在于它在水中的高溶解度,使其成为各种化学和生物应用中碘离子的有效来源。 它能够保护甲状腺免受放射性碘的伤害以及在碘量法滴定中的应用进一步突出了它的多功能性和重要性 .
生化分析
Biochemical Properties
Potassium iodide plays a significant role in biochemical reactions. It is used in colorimetric assays to detect hydrogen peroxide concentrations in leaf extracts . The method is based on the oxidation of this compound .
Molecular Mechanism
The molecular mechanism of this compound primarily involves its reaction with hydrogen peroxide. In this reaction, this compound is oxidized, indicating that it may interact with other biomolecules in a similar manner .
Metabolic Pathways
This compound is involved in the metabolic pathway of hydrogen peroxide detection, where it acts as a chromophore and undergoes oxidation .
准备方法
合成路线和反应条件: 碘化钾通常通过碘与氢氧化钾反应制备。该反应包括将碘溶解在水中,然后加入氢氧化钾溶液。将混合物加热至反应完全,形成碘化钾和水:
I2+2KOH→2KI+H2O
工业生产方法: 在工业环境中,碘化钾通过将碘添加到氢氧化钾溶液中制备。然后加热反应混合物,并将所得溶液蒸发至碘化钾结晶。 然后过滤、洗涤和干燥晶体,得到最终产品 {_svg_2}.
反应类型:
- 碘化钾可以通过各种氧化剂氧化为碘。例如:
氧化: 2KI+Cl2→2KCl+I2
还原: 碘化钾在某些反应中可以作为还原剂。
取代: 碘化钾用于亲核取代反应,将碘离子引入有机分子。
常见试剂和条件:
氧化剂: 氯气、溴气和其他卤素。
还原剂: 硫代硫酸钠、二氧化硫。
溶剂: 水、乙醇。
主要产品:
碘 (I₂): 在氧化反应中形成。
氯化钾 (KCl): 在与氯气的取代反应中形成 {_svg_3}
化学:
碘量法滴定: 碘化钾用作碘量法滴定中的分析试剂,以确定氧化剂的浓度。
芳香碘化物的合成: 它在芳香碘化物从重氮盐的合成中用作碘源.
生物学:
营养补充剂: 碘化钾添加到食盐中,以防止人类和动物的碘缺乏症。
甲状腺保护: 它用于在辐射事故中保护甲状腺免受放射性碘的伤害.
医药:
甲亢治疗: 碘化钾用于通过减少甲状腺激素的产生来治疗甲亢。
祛痰剂: 它有助于分解呼吸道中的粘液,使呼吸更容易.
工业:
摄影: 碘化钾用于制备感光乳剂。
染料制造: 它用作染料生产的原料.
相似化合物的比较
Potassium Iodate (KIO₃): Used as an iodine supplement in salt and for thyroid blocking in radiation emergencies.
Sodium Iodide (NaI): Used in similar applications as potassium iodide but with different solubility and reactivity properties.
Calcium Iodide (CaI₂): Used in animal feed and as a source of iodine in various applications
Uniqueness of this compound: this compound is unique due to its high solubility in water, making it an effective source of iodide ions in various chemical and biological applications. Its ability to protect the thyroid gland from radioactive iodine and its use in iodometric titrations further highlight its versatility and importance .
属性
IUPAC Name |
potassium;iodide | |
---|---|---|
Source | PubChem | |
URL | https://pubchem.ncbi.nlm.nih.gov | |
Description | Data deposited in or computed by PubChem | |
InChI |
InChI=1S/HI.K/h1H;/q;+1/p-1 | |
Source | PubChem | |
URL | https://pubchem.ncbi.nlm.nih.gov | |
Description | Data deposited in or computed by PubChem | |
InChI Key |
NLKNQRATVPKPDG-UHFFFAOYSA-M | |
Source | PubChem | |
URL | https://pubchem.ncbi.nlm.nih.gov | |
Description | Data deposited in or computed by PubChem | |
Canonical SMILES |
[K+].[I-] | |
Source | PubChem | |
URL | https://pubchem.ncbi.nlm.nih.gov | |
Description | Data deposited in or computed by PubChem | |
Molecular Formula |
KI, IK | |
Record name | POTASSIUM IODIDE | |
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Record name | potassium iodide | |
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URL | https://en.wikipedia.org/wiki/Potassium_iodide | |
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Source | PubChem | |
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DSSTOX Substance ID |
DTXSID7034836 | |
Record name | Potassium iodide | |
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Molecular Weight |
166.0028 g/mol | |
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Physical Description |
Potassium iodide is an odorless white solid. Sinks and mixes with water. (USCG, 1999), Dry Powder; Dry Powder, Liquid; Liquid; Pellets or Large Crystals, Other Solid, Water-soluble, white solid; [CAMEO] Slightly deliquescent; [CHEMINFO] | |
Record name | POTASSIUM IODIDE | |
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Record name | Potassium iodide (KI) | |
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Boiling Point |
Very high (USCG, 1999), 1323 °C | |
Record name | POTASSIUM IODIDE | |
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Record name | POTASSIUM IODIDE | |
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Solubility |
Slightly soluble in ethanol, 148 g/100 g water at 25 °C, 127.5 g sol in 100 cc water at 0 °C; 1.88 g sol in 100 cc alcohol at 25 °C; 1.31 g sol in 100 cc acetone at 25 °C; sol in ether, ammonia, 1 gram dissolves in 0.7 mL water, 0.5 mL boiling water; 51 mL absolute ethanol; 22 mL alcohol; 8 mL methanol; 75 mL acetone; 2 mL glycerol; about 2.5 mL glycol | |
Record name | POTASSIUM IODIDE | |
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Density |
3.13 at 59 °F (USCG, 1999) - Denser than water; will sink, 3.12 g/cu cm | |
Record name | POTASSIUM IODIDE | |
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Record name | POTASSIUM IODIDE | |
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Mechanism of Action |
In hyperthyroid patients, potassium iodide produces rapid remission of symptoms by inhibiting the release of thyroid hormone into the circulation. The effects of potassium iodide on the thyroid gland include reduction of vascularity, a firming of the glandular tissue, shrinkage of the size of individual cells, reaccumulation of colloid in the follicles, and increases in bound iodine. These actions may facilitate thyroidectomy when the medication is given prior to surgery., When administered prior to and following administration of radioactive isotopes and in radiation emergencies involving the release of radioactive iodine, potassium iodide protects the thyroid gland by blocking the thyroidal uptake of radioactive isotopes of iodine., The mechanism of action of potassium iodide's antifungal activity against Sporothix schenckii has not been determined. Potassium iodide does not appear to increase monocyte or neutrophil killing of S. schenckii in in vitro studies. However, exposure of the yeast form of S. schenckii to various concentrations of iodine (iodine and potassium iodide solution) has resulted in rapid cell destruction., Potassium iodide is thought to act as an expectorant by increasing respiratory tract secretions and thereby decreasing the viscosity of mucous ..., When potassium iodide is administered simultaneously with radiation exposure, the protectant effect is approximately 97%. Potassium iodide given 12 and 24 hours before exposure yields a 90% and 70% protectant effect, respectively. However, potassium iodide administered 1 and 3 hours after exposure results in an 85% and 50% protectant effect, respectively. Potassium iodide administered more than 6 hours after exposure is thought to have a negligible protectant effect. | |
Record name | POTASSIUM IODIDE | |
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Impurities |
Impurities: sulfates and heavy metals, Typically less than 1 ppm H2O-OH in 99.9995% purity, ultradry grades | |
Record name | POTASSIUM IODIDE | |
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Color/Form |
Colorless or white, cubical crystals, white granules, or powder, HEXAHEDRAL CRYSTALS, EITHER TRANSPARENT OR SOMEWHAT OPAQUE | |
CAS No. |
7681-11-0 | |
Record name | POTASSIUM IODIDE | |
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Record name | POTASSIUM IODIDE | |
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Melting Point |
1258 °F (USCG, 1999), 681 °C | |
Record name | POTASSIUM IODIDE | |
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Q1: How does potassium iodide interact with the thyroid gland?
A1: this compound provides the essential nutrient iodine, which the thyroid gland actively absorbs to produce the hormones thyroxine (T4) and triiodothyronine (T3). In situations of radioactive iodine exposure, this compound saturates the thyroid with stable iodine, blocking the uptake of the radioactive form and reducing the risk of thyroid cancer. []
Q2: Can this compound induce hyperthyroidism?
A2: Yes, in some cases, particularly in individuals with pre-existing thyroid conditions or those sensitive to iodine, this compound administration can lead to hyperthyroidism. This was observed in three geriatric patients receiving this compound during a 125I-fibrinogen test. []
Q3: What are the recommended daily allowances for iodine intake?
A3: The recommended daily allowances (RDA) for iodine intake are 150 μg in adults, 220–250 μg in pregnant women, and 250–290 μg in breastfeeding women. [] The American Thyroid Association (ATA) recommends that women take a multivitamin containing 150 μg of iodine daily in the form of this compound (KI) during preconception, pregnancy, and lactation to meet these needs. []
Q4: What is the effect of this compound on cathepsins in rat thyroid cells?
A6: Research using the FRTL thyroid cell line shows that high concentrations of this compound (50 mmol/L) significantly decrease the activity of cathepsins B and D. These enzymes play a role in thyroid hormone synthesis and release, suggesting iodine excess might affect thyroid function through this mechanism. []
Q5: What is the molecular formula and weight of this compound?
A5: The molecular formula of this compound is KI, and its molecular weight is 166.00 g/mol.
Q6: Can this compound be used as a photostabilizer?
A9: Yes, this compound solutions, which tend to turn yellow upon light exposure due to iodine liberation, can be stabilized using compounds like DL-methionine and thiourea. These compounds prevent color change even under intense light exposure for extended periods. []
Q7: How does this compound function as a catalyst?
A11: this compound can act as a catalyst in various reactions. For instance, it catalyzes the synthesis of 1,3-dioxolan-2-one derivatives from epoxides and carbon dioxide, even at relatively low temperatures (60°C). []
Q8: Is this compound truly a catalyst in the decomposition of hydrogen peroxide?
A12: Contrary to common belief, experimental evidence suggests that this compound is not a true catalyst in hydrogen peroxide decomposition. While it accelerates the reaction, it also undergoes chemical changes, as evidenced by the solution turning yellow due to iodine formation and changes in pH, conductivity, and iodide ion concentration. []
Q9: Can this compound be used in conjunction with biomass for CO2 conversion?
A13: Yes, research shows that dewaxed sugarcane bagasse combined with this compound can act as an effective catalytic system for converting CO2 to cyclic carbonates. The hydroxyl groups in the biomass play a crucial role in this process by activating the epoxide ring opening. []
Q10: Have computational methods been used to study this compound?
A14: Yes, molecular beam scattering data has been used to create highly accurate excited-state potential energy surfaces for this compound, furthering the understanding of its spectroscopic properties and behavior in excited states. []
Q11: Does the counterion to iodide affect iodine absorption?
A15: Yes, studies comparing this compound (KI) and sodium iodide (NaI) in rabbits showed that KI resulted in peak blood iodine levels being maintained for a longer duration compared to NaI. This suggests that the counterion can influence the pharmacokinetics of iodide. []
Q12: How can the stability of this compound formulations be improved?
A16: this compound jellied pharmaceutical compositions have been developed to improve storage stability and dissolution, allowing for easier medication. These formulations typically include gelling agents and dispersion media to achieve the desired properties. []
Q13: How is iodine absorbed and distributed in the body after this compound administration?
A17: Following oral administration, this compound is readily absorbed in the gastrointestinal tract. Iodine is then distributed throughout the body, with the thyroid gland actively accumulating it for hormone synthesis. Excess iodine is primarily excreted in urine. []
Q14: How does the absorption of iodine from this compound compare to that of iodine from kombu?
A18: Studies in rats have shown that the absorption of iodine from this compound is significantly higher compared to iodine from kombu, a type of seaweed. This difference was observed by comparing serum and tissue iodine concentrations in rats fed diets supplemented with either this compound or kombu powder. []
Q15: Can this compound be used to treat haemoptysis caused by aspergillomas?
A19: Yes, in cases where surgery is not an option, intracavitary instillation of sodium or this compound has been shown to be effective in stopping life-threatening haemoptysis from aspergillomas. []
Q16: What are the potential risks of excess iodine ingestion?
A20: Ingesting iodine in amounts exceeding the tolerable upper limits (1100 μg per day) can lead to thyroid dysfunction, particularly in susceptible individuals like infants, pregnant and breastfeeding women, the elderly, and those with pre-existing thyroid conditions. [] High iodine intake can cause effects ranging from goiter to hypothyroidism or hyperthyroidism. []
Q17: What analytical methods are used to determine iodide levels?
A21: Several methods are available for determining iodide levels, including volumetric titration methods like the Sadusk-Ball procedure, which is particularly useful for analyzing iodized salt. [] Other methods might include ion chromatography or spectrophotometry after appropriate chemical derivatization.
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